https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Vimentin Phosphorylation Is Required for Normal Cell Division of Immature Astrocytes https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45247 Wed 26 Oct 2022 20:03:45 AEDT ]]> Effects of ageing on the mitochondrial genome in rat vestibular organs https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35344 Wed 17 Jul 2019 11:45:17 AEST ]]> Insights into fetal death—a patient resource https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49912 Wed 14 Jun 2023 16:05:47 AEST ]]> The effect of gestational age on mitochondrial properties of the mouse placenta https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51670 Wed 13 Sep 2023 10:07:16 AEST ]]> Ageing of the inner ear vestibular organs https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35596 Wed 11 Sep 2019 14:24:41 AEST ]]> The trajectory of life. Decreasing physiological network complexity through changing fractal patterns https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27834 Wed 11 Apr 2018 18:16:09 AEST ]]> Investigation of equine fertility mechanisms through proteomic analysis of stallion spermatozoa, early equine embryos and pregnant mare uterine fluid https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27549 Wed 11 Apr 2018 14:20:32 AEST ]]> Rosiglitazone improves stallion sperm motility, ATP content, and mitochondrial function https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30037 Wed 11 Apr 2018 13:40:38 AEST ]]> Pacemaking in mouse locus coeruleus neurons: electrophysiological properties, role of mitochondria and development https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6901 Wed 11 Apr 2018 12:50:44 AEST ]]> Oxidative stress impairs mitochondrial function in healthy and asthmatic primary bronchial epithelial cells https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19268 Wed 11 Apr 2018 12:50:32 AEST ]]> Functional maturation of mouse epididymal spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:3122 Wed 11 Apr 2018 10:52:30 AEST ]]> Ultrastructural investigation and in vitro recapitulation of spermatid differentiation in a potential bio-indicator species - The marine invertebrate Galeolaria gemineoa (Polychaeta: Serpulidae) https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30799 Wed 11 Apr 2018 10:41:45 AEST ]]> Blocked, delayed, or obstructed: what causes poor white matter development in intrauterine growth restricted infants? https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31317 Wed 10 Nov 2021 15:05:04 AEDT ]]> Differential impact of four sperm preparation techniques on sperm motility, morphology, DNA fragmentation, acrosome status, oxidative stress, and mitochondrial activity: A prospective study https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43930 Wed 05 Oct 2022 12:37:22 AEDT ]]> Functional interactions between complex I and complex II with nNOS in regulating cardiac mitochondrial activity in sham and hypertensive rat hearts https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41423 Wed 03 Aug 2022 12:06:20 AEST ]]> Overexpression of Mitochondrial Catalase within Adipose Tissue Does Not Confer Systemic Metabolic Protection against Diet-Induced Obesity https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52575 Tue 17 Oct 2023 15:48:02 AEDT ]]> Energetic dysfunction is mediated by mitochondrial reactive oxygen species and precedes structural remodeling in metabolic heart disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48338 per se, is sufficient to cause contractile dysfunction in MHD.]]> Tue 14 Mar 2023 17:22:37 AEDT ]]> Causative mechanisms and functional correlates of MTT reduction in stallion spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53638 Tue 12 Dec 2023 16:36:04 AEDT ]]> Probing the origins of 1,800 MHz radio frequency electromagnetic radiation induced damage in mouse immortalized germ cells and spermatozoa in vitro https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35042 Tue 11 Jun 2019 14:20:01 AEST ]]> Crosstalk between mitochondria, calcium channels and actin cytoskeleton modulates noradrenergic activity of locus coeruleus neurons https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36209 c but does not exclude action at intracellular microdomains. Further to this, the incubation of slices with cytochalasin D, an agent that depolymerises the actin cytoskeleton, inhibited the hyperpolarizing response indicating an involvement of the actin cytoskeleton. The data are consistent with the hypothesis that there is a crosstalk between mitochondria and L-type Ca²⁺ channels leading to modulation of noradrenergic neuronal activity mediated by the actin cytoskeleton.]]> Tue 03 Mar 2020 15:35:08 AEDT ]]> Is mitochondrial dysfunction a driving mechanism linking COPD to nonsmall cell lung carcinoma? https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33773 Thu 27 Jan 2022 15:56:21 AEDT ]]> Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7232 Sat 24 Mar 2018 08:40:26 AEDT ]]> Mitochondria as a connected population: ensuring continuity of the mitochondrial genome during plant cell dedifferentiation through massive mitochondrial fusion https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1015 Sat 24 Mar 2018 08:29:47 AEDT ]]> Oxytocin depolarizes mitochondria in isolated myometrial cells https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12328 2+ concentration ([Ca2+]i), through enhancing extracellular Ca2+ entry and Ca2+ release from the sarcoplasmic reticulum, processes that are intimately linked with mitochondria. This study examined the effects of oxytocin on mitochondrial function. This was achieved by measuring the ratiometric JC-1 fluorescence signal in isolated myometrial cells, which provides a relative measure of the mitochondrial membrane potential (ψm), and also by loading the cells with Oregon Green BAPTA-AM to examine changes in [Ca2+]i. Oxytocin (1 nm) depolarized the ψm to 73.8 ± 3.7% of the control value (P < 0.05; perfused for 11 min) and also caused a transient increase in [Ca2+]i. The depolarization of mitochondrial membrane potential was effectively reversed by 2-aminoethoxydiphenyl borate, nifedipine, Ca2+-free solution or oligomycin, with the ratiometric JC-1 fluorescence signal becoming no different from the control value in all cases (i.e. P > 0.05). The reduction in ψm is likely to occur at least in part through the oxytocin-induced increase in [Ca2+]i, causing enhanced mitochondrial uptake of Ca2+ and resultant dissipation of the mitochondrial electrochemical gradient. ATP synthase is also stimulated, which would further contribute to a decrease in ψm.]]> Sat 24 Mar 2018 08:11:37 AEDT ]]> Role of mitochondria in contraction and pacemaking in the mouse uterus https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11410 Sat 24 Mar 2018 08:11:11 AEDT ]]> Stimulation of mitochondrial reactive oxygen species production by unesterified, unsaturated fatty acids in defective human spermatozoa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10153 Sat 24 Mar 2018 08:07:27 AEDT ]]> Melatonin prevents postovulatory oocyte aging in the mouse and extends the window for optimal fertilization in vitro https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20252 Sat 24 Mar 2018 07:59:55 AEDT ]]> Causes and consequences of apoptosis in spermatozoa; contributions to infertility and impacts on development https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19949 Sat 24 Mar 2018 07:58:32 AEDT ]]> Small molecular weight variants of p53 are expressed in human melanoma cells and are induced by the DNA-damaging agent cisplatin https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5341 Sat 24 Mar 2018 07:45:56 AEDT ]]> Investigation of Nicotiana tabacum (plus) N suaveolens cybrids with carpelloid stamens https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:142 Sat 24 Mar 2018 07:42:55 AEDT ]]> Design and rationale of a 16-week adjunctive randomized placebo-controlled trial of mitochondrial agents for the treatment of bipolar depression https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26171 Sat 24 Mar 2018 07:30:06 AEDT ]]> Ions, channels, and receptors https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:3157 Sat 24 Mar 2018 07:18:08 AEDT ]]> Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22207 R²= 0.89) in untreated populations of human spermatozoa emphasized the pathophysiological significance of these findings. The latter also provide a biochemical explanation for the self-perpetuating nature of oxidative stress in the male germ line, with the products of lipid peroxidation stimulating free radical generation by the sperm mitochondria in a positive feedback loop.]]> Sat 24 Mar 2018 07:11:16 AEDT ]]> Minimal adaptation of the molecular regulators of mitochondrial dynamics in response to unilateral limb immobilisation and retraining in middle-aged men https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50295 Sat 15 Jul 2023 11:43:00 AEST ]]> Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53265 Mon 20 Nov 2023 12:20:50 AEDT ]]> Mitochondrial Dynamin-Related Protein Drp1: a New Player in Cardio-oncology https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53264 Mon 20 Nov 2023 12:20:30 AEDT ]]> Metabolic Changes Accompanying Spermatogonial Stem Cell Differentiation https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40758 Mon 18 Jul 2022 13:54:17 AEST ]]> 'Multimorbidity' as the manifestation of network disturbances https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32646 within an individual in his or her socio-cultural environment. Networks include genomic, metabolomic, proteomic, neuroendocrine, immune and mitochondrial bioenergetic elements, as well as social, environmental and health care networks. Stress systems and other physiological mechanisms create feedback loops that integrate and regulate internal networks within the individual. Minor (e.g. daily hassles) and major (e.g. trauma) stressful life experiences perturb internal and social networks resulting in physiological instability with changes ranging from improved resilience to unhealthy adaptation and 'clinical disease'. Understanding 'multimorbidity' as a complex adaptive systems response to biobehavioural and socio-environmental networks is essential. Thus, designing integrative care delivery approaches that more adequately address the underlying disease processes as the manifestation of a state of physiological dysregulation is essential. This framework can shape care delivery approaches to meet the individual's care needs in the context of his or her underlying illness experience. It recognizes 'multimorbidity' and its symptoms as the end product of complex physiological processes, namely, stress activation and mitochondrial energetics, and suggests new opportunities for treatment and prevention. The future of 'multimorbidity' management might become much more discerning by combining the balancing of physiological dysregulation with targeted personalized biotechnology interventions such as small molecule therapeutics targeting specific cellular components of the stress response, with community-embedded interventions that involve addressing psycho-socio-cultural impediments that would aim to strengthen personal/social resilience and enhance social capital.]]> Mon 02 Jul 2018 16:18:12 AEST ]]> Mitochondrial small heat shock protein mediates seed germination via thermal sensing https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47862 Fri 03 Feb 2023 13:53:58 AEDT ]]>